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Published on: March 6, 2018
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Survival Differences in High-Risk Prostate Cancer by Age.
Clara García Fuentes1, Ana Guijarro2, Virginia Hernández3
1Department of Urology, Hospital Universitario Fundación Alcorcón, Madrid, Spain. cgarciaf@salud.madrid.org.
Urology Journal
|March 18, 2023
Summary
Age impacts overall survival in high-risk prostate cancer (PC). Older patients (>70) had poorer overall survival, but younger patients (<60) experienced higher biochemical recurrence rates. Age is an independent prognostic factor for overall survival in PC.
Area of Science:
- Oncology
- Geriatric Medicine
- Urology
Background:
- Age is a known prognostic factor in low-risk prostate cancer (PC), but its influence on high-risk PC survival is less clear.
- Understanding age-related survival differences in high-risk PC is crucial for treatment planning.
Purpose of the Study:
- To evaluate survival outcomes in patients with high-risk prostate cancer treated with curative intent.
- To identify age-specific differences in survival rates among patients diagnosed with high-risk PC.
Main Methods:
- Retrospective analysis of 378 patients with high-risk PC (excluding N+), treated with surgery or radiotherapy.
- Patients were stratified into age groups: <60, 60-70, and >70 years.
- Comparative and multivariate survival analyses were performed, adjusting for relevant clinical variables and initial treatment.
Main Results:
- Significant differences in overall survival were observed, favoring younger patients (<60 years).
- Younger patients (<60 years) showed a higher rate of biochemical recurrence at 10 years compared to older groups.
- Multivariate analysis identified age as an independent risk factor for overall survival, particularly in the >70 years group (HR 2.8).
Conclusions:
- Age is an independent prognostic factor for overall survival in high-risk prostate cancer patients.
- No significant age-related differences were found in other survival rates besides overall survival.
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