The novel HLA-DRB1*16:71 allele characterised by two different sequencing-based typing techniques

Area of Science:

• Immunogenetics
• Molecular biology

Background:

• Human leukocyte antigen (HLA) genes are crucial for immune response.
• Polymorphisms in HLA alleles contribute to diverse immune functions and disease susceptibility.

Purpose of the Study:

• To report the discovery and characterization of a novel HLA-DRB1 allele.

Main Methods:

• Sequence analysis of the HLA-DRB1 gene.
• Comparison of the novel allele sequence with known HLA-DRB1 alleles.

Main Results:

• A novel allele, designated HLA-DRB1*16:71, was identified.
• This new allele differs from the known HLA-DRB1*16:01:01:01 allele by a single non-synonymous nucleotide substitution in exon 2.

Conclusions:

• The identification of HLA-DRB1*16:71 expands the known HLA-DRB1 allele database.
• This finding contributes to a more comprehensive understanding of HLA polymorphism.