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Related Experiment Video

Updated: Aug 6, 2025

Isolation of Atrial Myocytes from Adult Mice
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Protocol for inducing cellular ablation in the mouse atrioventricular conduction system.

Lin Wang1, Jared Gabriel L Dela Rosa2, Nikhil V Munshi3

  • 1Department of Internal Medicine, Cardiology Division, UT Southwestern Medical Center, Dallas, TX 75390, USA.

STAR Protocols
|March 18, 2023
PubMed
Summary

This study introduces a mouse model to selectively damage the atrioventricular conduction system (AVCS), enabling research into cardiac conduction disorders and AVCS repair mechanisms.

Keywords:
Cell BiologyCell DifferentiationHealth SciencesMicroscopyModel Organisms

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Area of Science:

  • Cardiology
  • Molecular Biology
  • Regenerative Medicine

Background:

  • Damage to the atrioventricular conduction system (AVCS) can cause cardiac conduction disorders.
  • Understanding AVCS injury response is crucial for developing treatments.

Purpose of the Study:

  • To provide a protocol for selective AVCS damage in mice.
  • To facilitate the study of AVCS response to injury, repair, and regeneration.

Main Methods:

  • Tamoxifen-induced cellular ablation to target AVCS cells.
  • Electrocardiography to detect atrioventricular block.
  • Histological and immunofluorescence analysis to assess AVCS changes.

Main Results:

  • A reproducible protocol for inducing and analyzing AVCS damage in mice was established.
  • The model allows for detailed investigation of cellular and tissue responses to AVCS injury.

Conclusions:

  • This protocol serves as a valuable tool for studying the mechanisms of AVCS injury, repair, and regeneration.
  • It enables further research into potential therapeutic strategies for cardiac conduction disorders.