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Development of a Supramolecular Hydrogel for Intraperitoneal Injections.

Anne G W E Wintjens1,2, Peter-Paul K H Fransen3, Kaatje Lenaerts1,2

  • 1Department of Surgery, Maastricht University Medical Center+, Maastricht, 6202AZ, The Netherlands.

Macromolecular Bioscience
|March 19, 2023
PubMed
Summary
This summary is machine-generated.

A novel pH-sensitive supramolecular hydrogel enhances drug retention time for intraperitoneal delivery. This safe and biocompatible hydrogel demonstrates excellent tissue compatibility in rats, paving the way for improved local therapies.

Keywords:
animal modeldevelopmentin vivo safetyintraperitoneal deliveryperitoneal cavitysupramolecular hydrogel

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Regenerative Medicine

Background:

  • Intraperitoneal drug administration faces challenges due to rapid drug clearance, limiting therapeutic efficacy.
  • Developing effective drug delivery vehicles is crucial for enhancing local treatment outcomes.

Purpose of the Study:

  • To develop and evaluate a pH-sensitive supramolecular hydrogel for improved intraperitoneal drug retention.
  • To assess the safety, feasibility, and tissue compatibility of the hydrogel in preclinical models.

Main Methods:

  • Formulation of a pH-sensitive supramolecular hydrogel with optimized properties.
  • In vitro characterization of hydrogel viscosity at different pH levels.
  • Postmortem and in vivo assessments in rats to evaluate hydrogel distribution, safety, and tissue response over 14 and 28 days.

Main Results:

  • The hydrogel formulation exhibited a constant viscosity of 0.1 Pa·s at pH ≥ 9.
  • Postmortem analysis showed uniform coverage of peritoneal surfaces.
  • In vivo studies revealed no significant adverse effects, weight loss, or organ damage in rats; vacuolated macrophages indicated physiological degradation.

Conclusions:

  • The developed supramolecular hydrogel is safe and suitable for intraperitoneal drug delivery.
  • The hydrogel demonstrates excellent tissue compatibility and undergoes physiological degradation in vivo.
  • This technology holds promise for enhancing the efficacy of localized intraperitoneal therapies.