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On frailty and accelerated aging during SARS-Cov-2: senescence
Ursula Müller-Werdan1, M Cristina Polidori2,3, Andreas Simm4
1Department of Geriatrics and Medical Gerontology, Charité - Universitätsmedizin Berlin and EGZB, Berlin, Germany.
Cellular senescence, a key aspect of biological aging, significantly impacts COVID-19 outcomes. Understanding aging-associated risk factors is crucial for clinical decisions in managing the pandemic.
Area of Science:
- Gerontology
- Immunology
- Infectious Diseases
Background:
- COVID-19 poses a significant global health burden.
- Mortality risk in COVID-19 is age-dependent, with higher risks for multimorbid and frail individuals.
- Biological age, not just chronological age, influences COVID-19 outcomes.
Purpose of the Study:
- To review the role of cellular senescence in aging.
- To explore the connection between aging, inflammaging, and COVID-19.
- To highlight the importance of considering age-related factors in clinical decision-making for COVID-19 patients.
Main Methods:
- Literature review focusing on cellular senescence and aging.
- Analysis of studies linking biological aging markers to COVID-19 prognosis.
- Synthesis of information on inflammaging and its impact on organ function.
Main Results:
- Cellular senescence is a fundamental process of biological aging.
- Senescence contributes to organ dysfunction and chronic inflammation (inflammaging).
- Aging-associated risk factors are critical for understanding COVID-19 severity and outcomes.
Conclusions:
- Cellular senescence is a significant factor in age-related COVID-19 risk.
- Systematic consideration of physiological aging is essential for clinical management.
- Targeting senescence pathways may offer therapeutic potential for aging-related diseases and COVID-19.
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