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Health Supervision for Children and Adolescents With Marfan Syndrome

Brad T Tinkle1, Ronald V Lacro2, Leah W Burke3

  • 1Peyton Manning Children's Hospital, Ascension Healthcare, Indianapolis, Indiana.

Pediatrics
|March 20, 2023
PubMed

Insights

Marfan syndrome is a genetic disorder affecting connective tissues, with symptoms appearing from birth to adulthood. Early recognition and multidisciplinary care are crucial for managing this condition in children and adults.

Area of Science:

  • Genetics and Heritable Diseases
  • Connective Tissue Disorders
  • Pediatric Clinical Medicine

Background:

  • Marfan syndrome is a significant heritable connective tissue disorder impacting multiple organ systems.
  • Clinical manifestations can range from congenital presentation to emergence during childhood and adulthood.
  • Associated morbidity and mortality necessitate comprehensive management strategies.

Purpose of the Study:

  • To provide pediatricians with guidance on recognizing Marfan syndrome features.
  • To support pediatricians in managing individuals with Marfan syndrome.
  • To enhance health outcomes and quality of life for patients with Marfan syndrome.

Main Methods:

  • This clinical report synthesizes current knowledge on Marfan syndrome.
  • It focuses on diagnostic features relevant to pediatricians.
  • Management strategies emphasize a multidisciplinary approach.

Main Results:

  • The report details the diverse clinical manifestations of Marfan syndrome across different age groups.
  • It outlines key diagnostic indicators for pediatricians.
  • It stresses the importance of early identification and intervention.

Conclusions:

  • Early recognition of Marfan syndrome is vital for timely intervention.
  • A multidisciplinary care model optimizes patient outcomes.
  • Pediatricians play a key role in the lifelong management of Marfan syndrome.

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