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Updated: Aug 6, 2025

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
Published on: October 12, 2012
Quantitative Risk for Single-Positive Lupus Anticoagulant Results With Different Anticoagulants
Waleed Khan1, Christopher A Tormey1, Henry M Rinder1,2
1Department of Laboratory Medicine, New Haven CT, USA.
Objectives:
Clinical experts recommend against testing for lupus anticoagulant (LAC) during anticoagulation.
Methods:
We quantitated the risk of a single-positive dilute Russell viper venom time (dRVVT) result or partial thromboplastin time-based phospholipid neutralization (PN) result on anticoagulation.
Results:
Any anticoagulation led to a fourfold greater likelihood of single-positive results, primarily by rivaroxaban (odds ratio [OR] = 8.6) and warfarin (OR = 6.6), resulting in a positive dRVVT test with a normal PN test. Heparin and apixaban were twofold more likely to show single-positive results, but enoxaparin did not show significant single positivity.
Conclusions:
Our results quantitatively support experts' avoidance of LAC testing during anticoagulation.
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