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Updated: Mar 25, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
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Liquid plasma versus thawed plasma: Tracking coagulation factor activity changes during storage.

Nalan Yurtsever1, Catherine Gereg1, Nichelle Perera1

  • 1Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.

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|March 23, 2026
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Summary
This summary is machine-generated.

Liquid plasma (LQP) offers a viable alternative for emergency transfusions, showing comparable fibrinogen and protein C levels to thawed plasma (TP). While some factors like Factor V and Protein S are lower, LQP maintains stability for critical use.

Keywords:
coagulationfactor activityliquid plasmamassive transfusion protocolthawed plasma

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Area of Science:

  • Transfusion Medicine
  • Hematology
  • Biochemistry

Background:

  • Liquid plasma (LQP) presents a longer shelf-life alternative to thawed plasma (TP) for emergent transfusions.
  • Assessing coagulation factor levels in LQP is crucial for its clinical application.

Purpose of the Study:

  • To measure key coagulation factor activities (fibrinogen, Protein C, Protein S, Factor V, Factor VII, Factor VIII) in LQP.
  • To quantify changes in these factor levels during LQP storage.
  • To compare coagulation factor activity between LQP and TP.

Main Methods:

  • Coagulation factor activities were measured in LQP (n=26) on days 15 and 26, and in TP (n=31) on day 5.
  • Bayesian statistics were employed to compare factor activities and assess storage-related changes.

Main Results:

  • LQP on day 26 showed comparable fibrinogen and Protein C activity to TP on day 5.
  • Lower activities were observed in LQP for Factor V, Factor VII, Factor VIII, and significantly lower for Protein S.
  • Factor VII activity in LQP decreased by 3.49% daily from day 15 to 26, while other factors remained stable.

Conclusions:

  • Liquid plasma (LQP) demonstrates comparable fibrinogen, Protein C, and Factor VII levels to thawed plasma (TP).
  • Lower Factor V and Protein S, and slightly lower Factor VIII activities were noted in LQP.
  • LQP is a viable alternative for emergency and massive transfusion protocols.