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Related Concept Videos

Ultrasonography01:17

Ultrasonography

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Ultrasonography is an imaging technique that uses high-frequency sound waves to visualize the body's internal structures. It is a non-invasive and safe procedure that does not involve the use of ionizing radiation, making it widely used in various medical fields. Ultrasonography is used to study heart function, blood flow in the neck or extremities, certain conditions such as gallbladder disease, and fetal growth and development.
During an ultrasonography procedure, a handheld device called...
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Related Experiment Video

Updated: Aug 6, 2025

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release
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Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

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Nonspherical ultrasound microbubbles.

Anshuman Dasgupta1,2,3, Tao Sun2,3,4, Roberto Palomba5

  • 1Institute for Experimental Molecular Imaging, Medical Faculty, Rheinisch-Westfälische Technische Hochschule Aachen University, 52074 Aachen, Germany.

Proceedings of the National Academy of Sciences of the United States of America
|March 20, 2023
PubMed
Summary
This summary is machine-generated.

Researchers engineered nonspherical microbubbles (MB) for improved biomedical applications. These anisotropic MB demonstrated enhanced blood-brain barrier permeation and longer circulation times compared to spherical MB.

Keywords:
microbubblesnonsphericalshapesonoporationultrasound

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Surface tension naturally shapes microbubbles (MB) into spheres.
  • Engineering nonspherical MB offers potential for novel biomedical applications.

Purpose of the Study:

  • To engineer anisotropic microbubbles (MB) with unique features for biomedical applications.
  • To evaluate the performance of nonspherical MB compared to spherical MB.

Main Methods:

  • Anisotropic MB were fabricated by stretching spherical poly(butyl cyanoacrylate) MB above their glass transition temperature.
  • Performance was assessed through in vitro and in vivo studies, including margination behavior, macrophage uptake, circulation time, and blood-brain barrier (BBB) permeation with focused ultrasound (FUS).

Main Results:

  • Nonspherical polymeric MB exhibited increased margination in blood vessel-like flow.
  • Reduced macrophage uptake was observed in vitro.
  • Prolonged circulation time in vivo and enhanced BBB permeation with FUS were achieved.
  • Shape was identified as a critical design parameter for MB.

Conclusions:

  • Engineered nonspherical MB offer superior performance for biomedical applications.
  • Anisotropic MB provide a robust framework for ultrasound-enhanced drug delivery and imaging.