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Assisted Reproductive Technology Treatment Outcomes in Women With Liver Disease
Jessica D Lee1, Dmitry Gounko2, Joseph A Lee2
1Icahn School of Medicine at Mount Sinai (ISMMS), New York, New York, USA.
The American Journal of Gastroenterology
|March 20, 2023
Summary
Women with chronic liver disease (LD) can undergo assisted reproductive technology (ART) with similar success rates to those without liver disease. This study found comparable outcomes in controlled ovarian stimulation, fertilization, and live birth rates for patients with LD undergoing ART.
Area of Science:
- Reproductive Medicine
- Hepatology
- Infertility Treatment
Background:
- Women with chronic liver disease (LD) may face fertility challenges, necessitating evidence-based counseling.
- Existing literature on assisted reproductive technology (ART) in women with LD is limited.
Purpose of the Study:
- To evaluate ART treatment outcomes in women with LD.
- To compare ART outcomes between women with and without LD.
Main Methods:
- Retrospective study of women with and without LD undergoing ART (2002-2021).
- Inclusion criteria: normal ovarian reserve.
- Comparison of ART cycle outcomes, including controlled ovarian stimulation, fertilization, ploidy, and live birth rates.
Main Results:
- 295 women with LD underwent 1,033 ART cycles; 115 had 186 in vitro fertilization (IVF) cycles.
- No significant differences in ovarian stimulation response, fertilization rates, or ploidy between women with and without LD.
- Similar rates of clinical pregnancy, pregnancy loss, and live birth after single thawed euploid embryo transfer.
Conclusions:
- This is the largest study to date evaluating IVF efficacy in women with LD.
- Patients with LD demonstrate comparable ART treatment outcomes to those without LD.
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