Diterpenoid quinones from the Salvia miltiorrhiza and their lung protective activity
Ying-Jie Ren1, Yan-Gang Cao1, Meng-Nan Zeng1
1School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, PR China; Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of P.R. China, PR China.
Abstract:
Seven new diterpenoids quinones (1-6), together with five known ones (7-11), were isolated from the roots of Salvia miltiorrhiza Bunge. Their structures were elucidated by using 1D and 2D NMR data, while the relative and absolute configurations were confirmed by interpretations of the NOESY correlations and comparison of the experimental and calculated ECD spectra. In the evaluation of bioactivities, salviamilthiza C (3), significantly increased cell viability and decreased the expression of IL-1β in LPS-induced BEAS-2B cells.
