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Updates in the management of pediatric dyslipidemia

Pooja Choudhari1, Nivedita Patni

  • 1Division of Pediatric Endocrinology, Department of Pediatrics, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas 75390-9063, USA.

Current Opinion in Lipidology
|March 21, 2023
PubMed

Insights

Pediatric dyslipidemias increase cardiovascular risk. New medications like PCSK9 inhibitors and ANGPTL3 inhibitors show promise, complementing lifestyle changes and existing therapies for improved child cardiovascular health.

Area of Science:

  • Cardiology
  • Pediatric Endocrinology
  • Pharmacology

Background:

  • Pediatric dyslipidemias are a significant risk factor for atherosclerosis and cardiovascular disease in children.
  • Effective management of abnormal lipid levels is crucial for reducing long-term morbidity and mortality.

Approach:

  • This review examines current treatment standards for pediatric dyslipidemias.
  • It also explores emerging pharmacotherapies with potential to enhance cardiovascular health in pediatric and adult populations.

Key Points:

  • Statins, lifestyle interventions, bile acid sequestrants, and ezetimibe are current mainstays.
  • Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors and angiopoietin-like protein 3 (ANGPTL3) inhibitors are now approved or show promise for pediatric use.
  • Inclisiran, bempedoic acid, and lomitapide are under investigation in pediatric clinical trials.

Conclusions:

  • Pharmacotherapy advances, particularly for familial hypercholesterolemia, are transforming pediatric dyslipidemia treatment.
  • Further research is needed, especially for hypertriglyceridemia therapies, to mitigate atherosclerosis and cardiovascular risks in children.
Abstract

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