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DMSO potentiates aminonucleoside of puromycin nephrosis in rats
G S Spear1, D Nguyen, S Conklin
1Department of Pathology, California College of Medicine, University of California at Irvine 92717.
The Journal of Pathology
|October 1, 1987
Abstract:
Dimethyl sulphoxide (DMSO), 3 g/kg body weight, administered daily by the intraperitoneal route, potentiated the proteinuria and formation of tubular casts in aminonucleoside of puromycin (PA) induced nephrosis in Sprague-Dawley rats. The effect was evident at 4 as well as 8-9 days following PA administration. In the absence of PA, DMSO did not induce proteinuria or cast formation. The mechanism by which DMSO enhanced proteinuria and cast formation is not known.