Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Congenital agastria.

S F Dorney1, A W Middleton, K Kozlowski

  • 1Department of Gastroenterology, Royal Alexandra Hospital for Children, Camperdown, New South Wales, Australia.

Journal of Pediatric Gastroenterology and Nutrition
|March 1, 1987
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Early post-hatching effects of antibiotics and ionophore coccidiostat supplementation on immune parameters in turkeys.

Poultry science·2025
Same author

Efficacy of feeding spray-dried porcine plasma to turkeys during brooding on performance to market age.

Polish journal of veterinary sciences·2024
Same author

Retraction Note to: Stickler syndrome report of a second Australian family.

Pediatric radiology·2020
Same author

The effect of raw and fermented rapeseed cake on growth performance, carcass traits, and breast meat quality in turkey.

Poultry science·2019
Same author

Metabolic parameters in young turkeys fed diets with different inclusion levels of copper nanoparticles.

Polish journal of veterinary sciences·2018
Same author

The effect of manganese nanoparticles on performance, redox reactions and epigenetic changes in turkey tissues.

Animal : an international journal of animal bioscience·2018
Same journal

Foreign body ingestions in children and adolescents: A position paper of the ESPGHAN endoscopy special interest group.

Journal of pediatric gastroenterology and nutrition·2026
Same journal

Abdominal pain in pediatric immunoglobulin A vasculitis: Risk factors and severity predictors in a multicenter cohort.

Journal of pediatric gastroenterology and nutrition·2026
Same journal

Cognitive assessment in children with intestinal failure on and weaned off parenteral nutrition.

Journal of pediatric gastroenterology and nutrition·2026
Same journal

Safety of infant milks: Contamination with cereulide. A commentary by ESPGHAN (European Society for Paediatric Gastroenterology, Hepatology, and Nutrition).

Journal of pediatric gastroenterology and nutrition·2026
Same journal

ESPGHAN position paper on screening, diagnosis and investigation of paediatric metabolic dysfunction-associated steatotic liver disease.

Journal of pediatric gastroenterology and nutrition·2026
Same journal

Treatment outcomes and determinants of refractory peptic ulcer disease in children: A prospective study from Vietnam.

Journal of pediatric gastroenterology and nutrition·2026
See all related articles

This study reports the first case of congenital agastria, a rare condition where a baby is born without a stomach. The infant survived for nearly three years with a surgically created jejunal pouch, highlighting challenges in managing this condition.

Area of Science:

  • Pediatric Surgery
  • Gastroenterology
  • Medical Genetics

Background:

  • Congenital agastria, the complete absence of a stomach, is an extremely rare condition, with no prior documented cases.
  • Congenital microgastria, a significantly smaller stomach, is rare but has been previously reported in medical literature.

Observation:

  • A Melanesian infant presented with congenital agastria, lacking radiological, anatomical, or physiological evidence of a stomach or pylorus.
  • The esophagus directly connected to the duodenum, with microscopic fundic-type gastric mucosa found at the esophago-duodenal junction.
  • The infant also exhibited severe micrognathia and a cleft soft palate, necessitating a tracheostomy for airway obstruction.

Findings:

  • A surgically constructed jejunal pouch was used for nutritional delivery, enabling the child to grow and develop for almost three years.

Related Experiment Videos

  • The child experienced three episodes of severe acute enteritis, likely due to the absence of the protective acid-pepsin barrier.
  • The third episode of enteritis led to the child's death at three years of age.

    • Implications:

    • This case highlights the extreme rarity and significant management challenges associated with congenital agastria, particularly regarding nutrition and protection against enteric infections.
    • The findings underscore the critical role of gastric acid and pepsin in protecting the gastrointestinal tract from ingested microorganisms.
    • Further research into similar rare congenital gastrointestinal anomalies is warranted to improve understanding and clinical management strategies.