Therapeutic and Diagnostic Agents based on Bioactive Endogenous and Exogenous Coordination Compounds
1Department of Chemistry, Faculty of Pharmacy, Medical University-Sofia, 2 Dunav St., Sofia 1000, Bulgaria.
Current Medicinal Chemistry
|March 22, 2023
Summary
Metal-based coordination compounds are crucial in bioinorganic chemistry for medical applications. This review classifies these biologically active compounds by element position in the periodic table.
Area of Science:
- Bioinorganic Chemistry
- Medicinal Chemistry
- Coordination Chemistry
Background:
- Metal-based coordination compounds exhibit diverse structures and significant medical applications.
- These compounds play vital roles in biological systems, acting as endogenous or exogenous agents.
- Both essential and trace metals are utilized in metal-containing coordination compounds for therapeutic and diagnostic purposes.
Purpose of the Study:
- To review and classify important functional, biologically active metal-based coordination compounds.
- To organize these compounds based on elemental positions within the periodic table.
- To highlight advancements in the design and synthesis of metal-based pharmaceutical agents.
Main Methods:
- Systematic review of literature on metal-based coordination compounds.
- Classification of compounds based on periodic table group.
- Analysis of structural arrangements and biological functions.
- Evaluation of applications in diagnostic and therapeutic medicine.
Main Results:
- Categorization of key biologically active metal coordination compounds.
- Demonstration of the link between elemental position and compound function.
- Identification of trends in the development of metal-based drugs.
- Overview of diverse roles in medicine, from diagnostics to therapeutics.
Conclusions:
- Metal-based coordination compounds are indispensable in bioinorganic chemistry and medicine.
- Periodic table classification provides a useful framework for understanding these compounds.
- Continued research promises novel metal-based agents for health applications.
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