Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Assessment of the Rectum and Anus01:25

Assessment of the Rectum and Anus

313
Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
313
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

21
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
21
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

13
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs but also impacts other areas, such as the arms, thereby impairing overall circulation and organ function.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty deposits inside the arterial...
13
Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

331
The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
331
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

327
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
327
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

507
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
507

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Risk Factors for Small Bowel Crohn's Disease Recurrence after Total Proctocolectomy.

Diseases of the colon and rectum·2026
Same author

Constructive Conversations: Mastering the Exchange of Feedback.

Clinics in colon and rectal surgery·2026
Same author

Predicting Treatment Response After Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer.

Annals of surgery·2026
Same author

Watch and Wait in practice: Adherence to surveillance after nonoperative management for rectal cancer.

Surgery·2026
Same author

Selected Abstracts.

Diseases of the colon and rectum·2026
Same author

Robotic vs. laparoscopic redo ileocolonic resection for recurrent Crohn's disease.

Journal of robotic surgery·2026
Same journal

Prognostic impact of anal cancer morphology on survival and local recurrence: A 20-year regional cohort study.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2026
Same journal

Rethinking lymphadenectomy in the immunotherapy era of colorectal cancer: A hypothesis-generating perspective.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2026
Same journal

Transanal minimally invasive surgery for rectal GIST-A video vignette.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2026
Same journal

The relational core of nurse-led LARS care: Recognising an active therapeutic mechanism and building sustainable pathways.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2026
Same journal

Outcomes reported in comparative studies of surgical management of pilonidal disease: Systematic review to inform a core outcome set.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2026
Same journal

Robotic and transperineal endoscopic en bloc resection for rectal cancer with a rectovaginal fistula: Vaginal-wall fistula closure-A video vignette.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2026
See all related articles

Related Experiment Video

Updated: Aug 6, 2025

Anogenital Distance and Perineal Measurements of the Pelvic Organ Prolapse POP Quantification System
03:49

Anogenital Distance and Perineal Measurements of the Pelvic Organ Prolapse POP Quantification System

Published on: September 20, 2018

19.2K

Perianal Paget's-an aggressive disease.

Yaron Rudnicki1, Sahael M Stapleton1, Rishi Batra1

  • 1Division of Colon and Rectal Surgery, Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA.

Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland
|March 22, 2023
PubMed
Summary
This summary is machine-generated.

Perianal Paget's disease (PAPD) is an aggressive condition linked to anal adenocarcinoma. This study highlights high rates of synchronous and metachronous malignancy, impacting patient prognosis and treatment strategies.

Keywords:
abdominoperineal resectionanal cancercancer recurrenceperianal Paget's disease

More Related Videos

Demonstration of Cutaneous Allodynia in Association with Chronic Pelvic Pain
06:44

Demonstration of Cutaneous Allodynia in Association with Chronic Pelvic Pain

Published on: June 23, 2009

19.7K
Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
06:15

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

1.3K

Related Experiment Videos

Last Updated: Aug 6, 2025

Anogenital Distance and Perineal Measurements of the Pelvic Organ Prolapse POP Quantification System
03:49

Anogenital Distance and Perineal Measurements of the Pelvic Organ Prolapse POP Quantification System

Published on: September 20, 2018

19.2K
Demonstration of Cutaneous Allodynia in Association with Chronic Pelvic Pain
06:44

Demonstration of Cutaneous Allodynia in Association with Chronic Pelvic Pain

Published on: June 23, 2009

19.7K
Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
06:15

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

1.3K

Area of Science:

  • Gastroenterology
  • Surgical Oncology
  • Dermatology

Background:

  • Perianal Paget's disease (PAPD) is a rare malignancy with an uncertain prognosis.
  • Previous studies suggested a non-aggressive nature, but updated data is needed.

Purpose of the Study:

  • To describe the updated institutional experience with Perianal Paget's disease.
  • To analyze clinical manifestations, treatment outcomes, and oncological prognosis.

Main Methods:

  • Retrospective review of patients diagnosed with primary PAPD from 1991 to 2021.
  • Data collected included demographics, clinical and pathological features, treatments, recurrence, and survival.

Main Results:

  • Forty percent of patients had invasive anal adenocarcinoma at diagnosis.
  • Twenty-seven percent developed adenocarcinoma concurrently with PAPD recurrence.
  • Overall survival was 56% at 15 years, with a median survival of 16 years and 20% disease-related mortality.

Conclusions:

  • Perianal Paget's disease is an aggressive entity.
  • High rates of synchronous and metachronous anal adenocarcinoma are observed.
  • PAPD requires careful monitoring and management due to its association with malignancy.