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Updated: Aug 6, 2025
In Vitro and In Vivo Delivery of Magnetic Nanoparticle Hyperthermia Using a Custom-Built Delivery System
Published on: July 2, 2020
Design of a temperature-feedback controlled automated magnetic hyperthermia therapy device
Anirudh Sharma1, Avesh Avinash Jangam2, Julian Low Yung Shen2
1Department of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Introduction:
Magnetic hyperthermia therapy (MHT) is a minimally invasive adjuvant therapy capable of damaging tumors using magnetic nanoparticles exposed radiofrequency alternating magnetic fields. One of the challenges of MHT is thermal dose control and excessive heating in superficial tissues from off target eddy current heating.
Methods:
We report the development of a control system to maintain target temperature during MHT with an automatic safety shutoff feature in adherence to FDA Design Control Guidance. A proportional-integral-derivative (PID) control algorithm was designed and implemented in NI LabVIEW®. A standard reference material copper wire was used as the heat source to verify the controller performance in gel phantom experiments. Coupled electromagnetic thermal finite element analysis simulations were used to identify the initial controller gains.
Results:
Results showed that the PID controller successfully achieved the target temperature control despite significant perturbations.
Discussion And Conclusion:
Feasibility of PID control algorithm to improve efficacy and safety of MHT was demonstrated.
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