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[Recent research on cognitive impairment in children with acute lymphoblastic leukemia]
1Department of Hematology and Oncology, Shenzhen Children's Hospital, Shenzhen, Guangdong 518038, China.
Insights
Long-term survival in childhood acute lymphoblastic leukemia (ALL) is increasing, but many survivors face cognitive impairment. This review explores factors, detection, and treatments for cognitive issues in these children.
Area of Science:
- Pediatric Oncology
- Neuroscience
- Child Psychology
Background:
- Acute lymphoblastic leukemia (ALL) is the most common childhood cancer.
- Improved treatments lead to increased long-term survival rates for ALL patients.
- A significant number of ALL survivors experience cognitive impairment, impacting daily life.
Approach:
- This review synthesizes recent research on cognitive impairment in pediatric ALL survivors.
- It examines the various factors contributing to cognitive deficits.
- The review covers current detection techniques and emerging prevention/treatment strategies.
Key Points:
- Cognitive impairment in ALL survivors affects learning, employment, and social integration.
- Influencing factors include leukemia-related treatments (chemotherapy, radiation) and the disease itself.
- Early detection and targeted interventions are crucial for mitigating long-term cognitive effects.
Conclusions:
- Addressing cognitive impairment is essential for improving the quality of life for childhood ALL survivors.
- Further research is needed to optimize prevention and treatment protocols.
- A multidisciplinary approach is vital for comprehensive care of ALL survivors with cognitive challenges.
Abstract:
Acute lymphoblastic leukemia (ALL) is the most common malignant neoplastic disease in children. With the continuous improvement in diagnosis and treatment, there has been an increasing number of ALL children who achieve long-term survival after complete remission; however, a considerable proportion of these children have cognitive impairment, which has a serious adverse impact on their learning, employment, and social life. This article reviews the latest research on cognitive impairment in children with ALL from the aspects of the influencing factors, detection techniques, and prevention/treatment methods for cognitive impairment.
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