Related Experiment Video

Updated: Aug 6, 2025

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
13:24

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Published on: April 11, 2016

11.9K

Top advances of the year: Precision oncology

Aakash Desai1, Neha K Reddy2, Vivek Subbiah3,4,5

  • 1Division of Medical Oncology, MayoClinic, Rochester, Minnesota, USA.

Cancer
|March 22, 2023
PubMed

Insights

Precision oncology advances tumor genomic profiling for targeted therapies, improving cancer patient outcomes. Recent developments include novel treatments for previously undruggable mutations and antibody drug conjugates for lung cancer.

Area of Science:

  • Oncology
  • Genomics
  • Pharmacology

Background:

  • Precision medicine revolutionizes cancer care by integrating genomic profiling.
  • Actionable tumor aberrations guide targeted therapy selection and drug discovery.
  • Advances in next-generation sequencing (NGS) enable comprehensive tumor analysis.

Approach:

  • This review discusses recent breakthroughs in precision oncology.
  • Focuses on the clinical impact of genomic profiling and targeted therapies.
  • Highlights the development of novel therapeutic agents and delivery methods.

Key Points:

  • Targeted agents for KRASG12C, Exon 20 insertions, and RET mutations show rapid clinical development.
  • Antibody drug conjugates represent a new approach to precision chemotherapy in lung cancer.
  • Liquid biopsy and tumor tissue sequencing are integral to precision oncology.

Conclusions:

  • Precision oncology has significantly improved outcomes for cancer patients.
  • Genomic-driven therapies are transforming oncologic practice.
  • Continued research in targeted agents and delivery systems is crucial.
Keywords:
antibody drug conjugatescanceroncogenic driverprecision oncologytargeted therapy

More Related Videos

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer07:59

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer

Published on: September 8, 2023

1.2K
Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology07:03

Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology

Published on: December 1, 2023

973

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.8K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.0K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.4K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.9K
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
601