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Related Concept Videos

Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

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Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
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Related Experiment Video

Updated: Aug 6, 2025

Closure of a Patent Foramen Ovale PFO: An Intervention Sequence
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Post-infarction ventricular septal defect surgery in Portugal.

Pedro Magro1, André Soeiro2, Nuno Guerra3

  • 1Department of Cardio-thoracic Surgery, Hospital de Santa Cruz, Carnaxide, Portugal.

Revista Portuguesa De Cardiologia : Orgao Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
|March 22, 2023
PubMed
Summary
This summary is machine-generated.

Delayed surgical closure of ventricular septal defects (VSD) after myocardial infarction may improve survival. While age and concomitant coronary artery bypass grafting (CABG) impact 30-day mortality, the optimal timing for VSD repair remains debated.

Keywords:
Complicação mecânicaComunicação interventricularEnfarte agudo do miocárdioMechanical complicationMyocardial infarctionRegistoRegistryVentricular septal defect

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Area of Science:

  • Cardiology
  • Cardiac Surgery
  • Clinical Research

Background:

  • Post-myocardial infarction ventricular septal defect (VSD) is a severe complication.
  • Surgical treatment strategies for VSD remain controversial.

Purpose of the Study:

  • To analyze a national registry of post-myocardial infarction VSD.
  • To elucidate controversial aspects of surgical treatment for VSD.

Main Methods:

  • Descriptive statistical analysis of a dedicated national VSD registry.
  • Kaplan-Meier survival analysis and multivariate logistic regression for risk factors of 30-day mortality.

Main Results:

  • Median survival for the cohort (n=76) was 72 months.
  • Improved cumulative survival was observed with VSD closure >10 days post-myocardial infarction (p=0.036).
  • Age (OR 1.08) and concomitant CABG (OR 0.23) were significant independent factors for 30-day mortality.

Conclusions:

  • Results align with previous reports on mortality and risk factors.
  • Later VSD closure appears advantageous, but significant observational bias exists.
  • Optimal surgical timing for post-myocardial infarction VSD requires further investigation.