Granulocyte Colony-stimulating Factor-associated Aortitis on Gallium Scintigraphy
Haruka Ozaki1, Kohji Takemura1, Rika Kizawa1
1Department of Medical Oncology, Toranomon Hospital, Japan.
Internal Medicine (Tokyo, Japan)
|March 22, 2023
Summary
Gallium scintigraphy may aid in diagnosing rare granulocyte colony-stimulating factor (G-CSF)-associated aortitis. This imaging technique showed inflammation in arterial walls, supporting its use when contrast CT is not feasible.
Area of Science:
- Nuclear Medicine
- Radiology
- Cardiovascular Imaging
Background:
- Aortitis is a rare adverse event linked to granulocyte colony-stimulating factor (G-CSF).
- Contrast-enhanced computed tomography (CECT) is the standard diagnostic tool for G-CSF-associated aortitis.
- The diagnostic utility of gallium scintigraphy for this condition remains unexplored.
Purpose of the Study:
- To evaluate the potential role of gallium scintigraphy in diagnosing G-CSF-associated aortitis.
- To present a case study illustrating the use of gallium scintigraphy in conjunction with CECT.
Main Methods:
- Case report of a patient with G-CSF-associated aortitis.
- Pre- and post-treatment gallium scintigrams were obtained.
- Findings were correlated with contrast-enhanced computed tomography (CECT) results.
Main Results:
- Gallium scintigraphy identified "hot spots" on arterial walls corresponding to inflammation seen on CECT.
- Both CECT and gallium scintigraphy findings resolved after treatment.
- Gallium scintigraphy demonstrated inflammation in the arterial walls.
Conclusions:
- Gallium scintigraphy can serve as a supportive diagnostic tool for G-CSF-associated aortitis.
- It is particularly valuable for patients with renal impairment or iodine contrast allergy.
- This technique offers an alternative imaging modality for diagnosing G-CSF-induced aortitis.
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