Related Experiment Video

Updated: Aug 6, 2025

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
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The Promise of Neoadjuvant and Adjuvant Therapies for Renal Cancer

Jeffrey J Leow1, Shagnik Ray2, Shawn Dason2

  • 1Department of Urology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Annex 1-L04-Uro, Singapore 308433, Singapore.

The Urologic Clinics of North America
|March 22, 2023
PubMed

Insights

Systemic therapies, including anti-VEGF tyrosine kinase inhibitors (TKIs) and immunotherapy, are being researched for localized renal cell carcinoma (RCC). These treatments aim to improve surgical outcomes and patient survival rates.

Area of Science:

  • Oncology
  • Nephrology
  • Pharmacology

Background:

  • Metachronous metastatic disease affects 20-40% of localized renal cell carcinoma (RCC) patients post-surgery.
  • Improving disease-free and overall survival in RCC necessitates novel therapeutic strategies.

Purpose of the Study:

  • To investigate the role of neoadjuvant and adjuvant systemic therapies in enhancing outcomes for localized renal cell carcinoma (RCC).
  • To evaluate the efficacy of anti-vascular endothelial growth factor (VEGF) tyrosine kinase inhibitors (TKIs) and immunotherapy in RCC management.

Main Methods:

  • Review of neoadjuvant therapies including anti-VEGF TKI agents and combination therapies (immunotherapy with TKI).
  • Analysis of adjuvant therapies such as cytokines, anti-VEGF TKI agents, and immunotherapy.

Main Results:

  • Neoadjuvant therapies aim to improve the resectability of locoregional RCC.
  • Adjuvant therapies have shown potential in improving disease-free survival post-surgery.

Conclusions:

  • Systemic therapies offer a promising approach to improve surgical extirpation and survival in RCC patients.
  • Further research into neoadjuvant and adjuvant treatments is crucial for optimizing RCC patient outcomes.
Keywords:
Adjuvant therapyImmunotherapyKidney neoplasmsNeoadjuvant therapyRadical nephrectomyRenal cancerSystemic therapyTargeted therapy

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