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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
Published on: January 7, 2019
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Parasites as potential targets for cancer immunotherapy
Morteza Yousefi1, Mohammadesmail Akbari2, Mahboubeh Hadipour3
1Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Journal of Cancer Research and Clinical Oncology
|March 23, 2023
Summary
Parasites exhibit significant anti-cancer effects, potentially through direct impact or immune responses to shared antigens. Future cancer therapies may leverage parasites or their antigens for treatment.
Area of Science:
- Parasitology and Oncology
- Immunology
Background:
- Parasites and cancer share common antigens.
- Evidence suggests parasites possess anti-cancer properties.
- Research has focused on specific parasites like Echinococcus granulosus and Toxoplasma gondii.
Purpose of the Study:
- To review the anti-cancer effects of parasites.
- To explore the mechanisms behind these anti-tumor effects.
- To discuss the future potential of parasite-based cancer treatments.
Main Methods:
- Literature review of scientific evidence.
- Analysis of in vitro, animal model, and human population studies.
- Examination of research on specific parasite species.
Main Results:
- Parasites demonstrate significant anti-cancer effects.
- Mechanisms include direct parasite impact and immune responses to shared antigens.
- Several parasite species are under investigation for anti-cancer properties.
Conclusions:
- Parasites offer a promising avenue for cancer treatment.
- Further research into parasite-host interactions is warranted.
- Utilizing parasites or their antigens could lead to novel cancer therapies.
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