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Updated: Aug 6, 2025

Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b
Published on: November 11, 2016
Optimized synthesis and pharmacological evaluation of HCN channel inhibitor EC18
Marius Patberg1, Tengiz Oniani2, Paul Disse3
1European Institute for Molecular Imaging (EIMI), Münster, Germany.
Abstract:
HCN4 channels are considered to be a promising target for cardiac pathologies, epilepsy, and multiple sclerosis. However, there are no subtype-selective HCN channel blockers available, and only a few compounds are reported to display subtype preferences, one of which is EC18 (cis-1). Herein, we report the optimized synthetic route for the preparation of EC18 and its evaluation in three different pharmacological models, allowing us to assess its activity on cardiac function, thalamocortical neurons, and immune cells.
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