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Related Concept Videos

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Related Experiment Video

Updated: Aug 6, 2025

Application of Hemostatic Devices in Laparoscopic Hepatectomy
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Application of cardiovascular interventions to decrease blood loss during hepatectomy: a systematic review and

Hui Ye1, Hanghang Wu2, Bin Li3

  • 1Department of Anesthesiology, ZhongDa Hospital, Southeast University, No. 87 Dingjiaqiao, Gulou District, Nanjing, Jiangsu Province, 210009, China. carciapene@126.com.

BMC Anesthesiology
|March 23, 2023
PubMed
Summary
This summary is machine-generated.

Lowering central venous pressure (CVP) during hepatectomy significantly reduces blood loss and transfusion needs. Acute normovolaemic haemodilution and autologous blood donation also decrease transfusion requirements, improving patient outcomes.

Keywords:
Blood lossCardiovascular interventionsHepatectomyMeta-analysisTransfusion

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Area of Science:

  • Hepatobiliary surgery
  • Anesthesiology
  • Transfusion medicine

Background:

  • Perioperative bleeding and allogeneic blood transfusions impact patient outcomes in hepatectomy.
  • This meta-analysis evaluates cardiovascular interventions for managing blood loss and transfusion during liver resections.

Approach:

  • Systematic review and meta-analysis of randomized controlled trials (RCTs) up to February 2023.
  • Included RCTs focused on interventions to reduce blood loss or transfusion in hepatectomy patients.
  • Primary outcomes: blood loss, transfusion rates, and postoperative complications; Secondary outcomes: operating time, mortality, organ function, and hospital stay.

Key Points:

  • Low central venous pressure (CVP) group showed significantly less operative bleeding (MD: -409.75 mL), reduced transfusion rates (RR: 0.47), shorter operating times (MD: -13.42 min), and fewer complications (RR: 0.76) compared to controls.
  • Acute normovolaemic haemodilution (ANH) and autologous blood donation reduced transfusion needs but not blood loss.
  • No significant benefits observed for mortality rates or hospital stay length across interventions.

Conclusions:

  • Maintaining a low CVP is an effective and safe strategy for adult hepatectomy patients.
  • ANH and autologous blood donation can be valuable components of blood management for selected patients.
  • Further research may explore optimizing these strategies to further improve surgical outcomes.