Role of OAS gene family in COVID-19 induced heart failure

Related Experiment Video

Updated: Aug 6, 2025

Viral Transgene Expression in Rodent Hearts and the Assessment of Cardiac Arrhythmia Risk
05:15

Viral Transgene Expression in Rodent Hearts and the Assessment of Cardiac Arrhythmia Risk

Published on: July 27, 2022

1.7K

Li-Juan Gao1, Zhong-Mei He2, Yi-Ying Li2

  • 1Key Laboratory of Cellular Physiology, Department of Physiology, Ministry of Education, Shanxi Medical University, Taiyuan, 030001, Shanxi, People's Republic of China. gaolijuan@sxmu.edu.cn.

Journal of Translational Medicine
|March 23, 2023
PubMed
Abstract

Insights

The 2

Area of Science:

  • Cardiology
  • Virology
  • Immunology

Background:

  • COVID-19 (SARS-CoV-2) infection can cause cardiac damage, leading to heart failure (HF).
  • The 2',5'-oligoadenylate synthetase (OAS) gene family plays a role in antiviral immune responses.
  • The association between OAS genes and COVID-19-related cardiac injury was previously undetermined.

Purpose of the Study:

  • To investigate the expression and function of OAS gene family in COVID-19-associated cardiac injury.
  • To explore regulatory mechanisms including microRNAs and chemicals impacting OAS gene expression in heart failure.

Main Methods:

  • Bioinformatic analysis of SARS-CoV-2 infected cardiomyocytes (GSE150392) and heart failure (GSE120852) datasets.
  • Experimental validation of OAS gene expression and function.
  • Analysis of microRNA targets and prediction of regulatory chemicals using databases like CTD and SymMap.

Main Results:

  • OAS genes were highly expressed in both infected cardiomyocytes and failing hearts.
  • Enrichment analysis revealed associations with cardiovascular disease and COVID-19 pathways.
  • Ten microRNAs were identified as potential regulators of OAS gene expression, with estradiol predicted as a key regulatory chemical.

Conclusions:

  • The OAS gene family is implicated as a mediator of heart failure in COVID-19 patients.
  • OAS genes represent a potential therapeutic target for managing cardiac injury and heart failure in COVID-19.
Keywords:
COVID-19CardiomyocyteHeart failureOAS gene familySARS-CoV-2

More Related Videos

Gene Transfer for Ischemic Heart Failure in a Preclinical Model07:35

Gene Transfer for Ischemic Heart Failure in a Preclinical Model

Published on: May 15, 2011

12.9K
Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

3.2K

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
19
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.7K
Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
244
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
19
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
478
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
18