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Published on: February 17, 2023
Pt-N Coordination Rendering the Chemotherapeutic Agent with Photoactivated ROS Generation and Self-Reporting Cell
Shen Wang1, Yingcui Bu1, Jie Zhang1
1School of Chemistry and Chemical Engineering, Institute of Physical Science and Information Technology, Anhui University and Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials, Key Laboratory of Structure and Functional Regulation of Hybrid Materials (Anhui University) Ministry of Education, Hefei 230601, P. R. China.
This study developed a novel chemotherapy drug (MSN-Pt) that uses light to generate reactive oxygen species (ROS) and report cancer cell uptake, overcoming toxic side effects and inhibiting tumor growth in mice.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Materials Science
Background:
- Chemotherapeutic agents like cisplatin (CDDP) face limitations due to dose-dependent toxic side effects.
- Developing targeted drug delivery systems is crucial for enhancing efficacy and reducing toxicity.
Purpose of the Study:
- To create a photoactivated chemotherapy drug delivery system (MSN-Pt) that generates reactive oxygen species (ROS) and self-reports cancer cell uptake.
- To improve the therapeutic index of chemotherapy for drug-resistant cancers.
Main Methods:
- Coordination of cisplatin (CDDP) with a mesoporous silica nanoparticle (MSN) to form MSN-Pt.
- Utilizing Pt-N coordination to enhance intermolecular charge transfer (ICT) for integrated fluorescence imaging, ROS generation, and chemotherapy.
- Evaluating cellular uptake, targeting of normal versus cancer cells, and photodynamic damage to mitochondria and nuclei.
- Assessing *in vivo* tumor inhibition efficacy in a mouse model.
Main Results:
- MSN-Pt demonstrated enhanced ICT, enabling fluorescence imaging, ROS generation, and chemotherapy.
- MSN-Pt effectively recognized and penetrated cancer cell membranes, self-reporting cellular uptake.
- Light illumination of MSN-Pt caused severe damage to cancer cell mitochondria and nuclei.
- *In vivo* studies showed complete inhibition of tumor growth with MSN-Pt, outperforming CDDP.
Conclusions:
- MSN-Pt offers a facile strategy for developing advanced chemotherapy drugs.
- This approach shows significant potential for treating drug-resistant cancers by combining targeted delivery, imaging, and photodynamic therapy.
- The self-reporting capability enhances monitoring of drug delivery and therapeutic response.
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