[Is ketogenic diet effective against cancer ?]

Area of Science:

• Oncology
• Metabolic Medicine
• Nutritional Science

Background:

• The ketogenic diet (KD) is established for treating intractable epilepsy in children.
• Growing evidence suggests potential therapeutic roles for the KD in neurodegenerative diseases, metabolic syndrome, and cancer.
• Cancer remains a significant global health challenge, driving research into complementary therapies.

Approach:

• This review examines the scientific evidence for the ketogenic diet as an adjunctive cancer therapy.
• It discusses the potential mechanisms by which the KD may impact cancer.
• Practical considerations for implementing the KD in oncology settings are also addressed.

Key Points:

• The KD involves very low carbohydrate, moderate protein, and high fat intake.
• Preclinical and some clinical studies suggest the KD may influence tumor metabolism and growth.
• Potential benefits include improved response to chemotherapy and radiotherapy, and reduced side effects.

Conclusions:

• The ketogenic diet shows promise as a complementary approach in cancer care.
• Further rigorous clinical trials are needed to establish its efficacy and optimal use.
• Integrating the KD requires careful patient selection and monitoring by a multidisciplinary team.