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Effects of Aspirin on Kidney Biopsy Bleeding Complications: A Systematic Review and Meta-Analysis (PROSPERO 2021

Miguel Relvas1, Joana Gonçalves2, Inês Castro2

  • 1Nephrology Department, Centro Hospitalar Universitário de São João, Porto, Portugal.

Kidney360
|March 23, 2023
PubMed

Insights

Aspirin use does not significantly increase major bleeding risk after percutaneous kidney biopsy (PKB). This meta-analysis found no significant difference in bleeding events between patients taking aspirin and those who were not.

Area of Science:

  • Nephrology
  • Cardiology
  • Clinical Research

Background:

  • Postprocedural bleeding is a primary complication of percutaneous kidney biopsy (PKB).
  • Aspirin is typically withheld before PKB to mitigate bleeding risks.
  • The association between aspirin use and bleeding complications following PKB requires further investigation.

Approach:

  • A systematic review and meta-analysis were conducted following PRISMA guidelines.
  • Literature searches were performed on MEDLINE and Scopus, including only primary studies.
  • A meta-analysis compared major bleeding events in aspirin-exposed versus non-exposed groups, using random-effects modeling.

Key Points:

  • Ten studies were reviewed, with four included in the meta-analysis, encompassing 34,067 PKBs.
  • Inconsistent definitions of aspirin exposure across studies limited direct comparisons.
  • No significant increase in major bleeding events was observed in aspirin-exposed patients (OR 1.72; 95% CI 0.50 to 5.89).

Conclusions:

  • Current high-quality evidence regarding aspirin's effect on PKB bleeding risk is limited.
  • This meta-analysis suggests aspirin use is not associated with a significantly increased risk of major bleeding complications post-PKB.
  • Further research is needed to establish optimal clinical guidelines for aspirin management in patients undergoing PKB.

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