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Related Concept Videos

Gene Families01:57

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Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
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Hemoglobin is a globular protein made up of four subunits. Two of these subunits are alpha chains, and the other two are beta chains. Each subunit contains a molecule of heme, which has an iron atom and can bind to oxygen. When an oxygen molecule binds to one heme group, it changes the shape of hemoglobin, making it easier for the other heme groups to bind oxygen as well.
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Staphylococcus aureus Growth using Human Hemoglobin as an Iron Source
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Hemoglobin Louisville: A Case Report.

Ionela Morosanu1, Yaniv Ergas2, Martina Cade3

  • 1is staff CRNA University of Maryland Medical Center Baltimore, Maryland.

AANA Journal
|March 23, 2023
PubMed
Summary
This summary is machine-generated.

This case study highlights anesthetic management for a patient with Hemoglobin Louisville, a rare genetic condition. Understanding hemoglobinopathies is crucial for perioperative care, especially with low baseline oxygen saturation.

Keywords:
Hemoglobin BucurestiHemoglobin Louisvillehemoglobin-oxygen affinityhemoglobinopathieshypoxia

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Area of Science:

  • Anesthesiology
  • Hematology
  • Genetics

Background:

  • Case study of a patient with Hemoglobin Louisville, a rare hemoglobinopathy.
  • Patient presented with baseline low oxygen saturation (SpO2) in the 80s.
  • Focus on anesthetic management during an elective procedure.

Observation:

  • Noninvasive pulse oximetry revealed persistently low SpO2.
  • The patient's medical history included Hemoglobin Louisville.
  • Anesthesia details and physiological review are presented.

Findings:

  • Discussion of the physiological implications of Hemoglobin Louisville.
  • Analysis of the anesthetic approach for this specific genetic mutation.
  • Low SpO2 in patients with rare hemoglobin variants requires careful consideration.

Implications:

  • Highlights the importance of understanding rare hemoglobinopathies for anesthesia providers.
  • Emphasizes the need for tailored perioperative care strategies.
  • Informs the anesthesia community on managing patients with unexpected hypoxemia due to genetic factors.