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Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography
Published on: February 17, 2022
Hit and Run: Bilateral Massive Intraocular Lymphomatous Infiltration after CAR-T Therapy
Abdullah Abou-Samra1, Sloane McTavish2, Rachel Whitehair3
1Department of Ophthalmology, University of Virginia, Charlottesville, Virginia, USA.
Purpose:
We report a case of bilateral intraocular infiltration of DLBCL after CAR-T therapy.
Methods:
Retrospective case report.
Results:
A 62-year-old Caucasian male with medical history of high-grade DLBCL presented with papillitis and vitritis upon completion of CAR-T therapy. Thorough infectious and diagnostic work-ups were performed. Diagnostic vitreous tap revealed intraocular lymphoma. The patient received external beam radiotherapy to both orbits with dramatic improvement in disc edema and vitritis. However, subsequent MRI showed development of intracranial metastatic disease, and the patient died within the same month.
Conclusion:
Atypical intraocular metastasis of DLBCL may occur following CAR-T therapy and may indicate secondary changes in immunosurveillance within immune-privileged sites such as the eye.

