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Related Concept Videos

Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

20
Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
20
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

20
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
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Cardiac Catheterization III: Left Heart Catheterization01:24

Cardiac Catheterization III: Left Heart Catheterization

112
Left heart catheterization is an invasive diagnostic procedure used to evaluate the function and structure of the left side of the heart. It is generally performed to diagnose and treat cardiovascular conditions such as valve abnormalities, coronary artery disease, and congenital heart defects.Diagnostic and therapeutic purposesLeft heart catheterization serves various diagnostic and therapeutic purposes, including:Assessing coronary artery bypass grafts.Evaluating coronary artery disease in...
112
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

14
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
14
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

18
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
18

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Reverse Remodeling Induced by Transcatheter Left Ventricular Restoration System Is Sustained Through 2 Years of Follow-Up.

Structural heart : the journal of the Heart Team·2025
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Transcatheter Aortic Valve Replacement in Oncology Patients With Severe Aortic Stenosis.

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Related Experiment Video

Updated: Aug 5, 2025

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock
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Transcatheter Left Ventricular Restoration in Patients With Heart Failure.

Nadira Hamid1, Ulrich P Jorde2, Mark Reisman3

  • 1Columbia University Medical Center/ NY Presbyterian Hospital, New York, New York; Cardiovascular Research Foundation, New York, New York.

Journal of Cardiac Failure
|March 23, 2023
PubMed
Summary

Transcatheter left ventricular restoration using the AccuCinch system reduced left ventricular volume and improved quality of life in heart failure patients. This minimally invasive procedure offers a promising option for managing heart failure with reduced ejection fraction.

Keywords:
Transcatheterheart failureleft ventricle

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Area of Science:

  • Cardiology
  • Medical Devices
  • Heart Failure Research

Background:

  • Left ventricular (LV) volume reduction aims to decrease myocardial wall stress and promote reverse remodeling in heart failure with reduced ejection fraction (HFrEF).
  • The AccuCinch Transcatheter Left Ventricular Restoration system is a novel device designed to reshape the LV by cinching the basal free wall radius.

Purpose of the Study:

  • To evaluate the echocardiographic and clinical outcomes of transcatheter left ventricular restoration using the AccuCinch system in HFrEF patients.
  • To assess the impact of LV volume reshaping on LV dimensions, quality of life, and exercise capacity.

Main Methods:

  • A cohort of 51 HFrEF patients (LVEF 20-40%) on optimal medical therapy underwent transcatheter left ventricular restoration.
  • Serial echocardiograms, Kansas City Cardiomyopathy Questionnaire (KCCQ) scores, and 6-minute walk test (6MWT) distances were collected at baseline and up to 12 months.
  • The primary endpoint was the change in LV end-diastolic volume (LVEDV) at 12 months compared to baseline.

Main Results:

  • The AccuCinch procedure resulted in a significant decrease in LV end-diastolic volume (33.6 ± 34.8 mL; P < .01) and LV end-systolic volume.
  • LV free wall radius decreased by a median of 9.2 mm (29.6% decrease in free wall arc length).
  • Significant improvements were observed in KCCQ scores (16.4 ± 18.7 points; P < .01) and 6MWT distance (45.9 ± 83.9 m; P < .01).

Conclusions:

  • Transcatheter left ventricular restoration with the AccuCinch system effectively reduces LV volume in HFrEF patients without significant mitral regurgitation.
  • The procedure is associated with significant improvements in quality of life and exercise endurance.
  • A randomized trial is currently underway to further validate these findings.