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Updated: Aug 5, 2025

Biochemical Measurement of Neonatal Hypoxia
Published on: August 24, 2011
Rates of phototherapy among ABO-incompatible newborns with a negative direct antiglobulin test
Jonathan M Gabbay1,2, Elizabeth M Agneta3,4, Simon Turkington5
1Department of Medicine, Boston Children's Hospital, Boston, MA, USA. jonathan.gabbay@childrens.harvard.edu.
Objective:
We analyze phototherapy rates after implementation of a Hyperbilirubinemia Clinical Pathway (HCP), which placed full-term ABOi DAT negative newborns on the low risk phototherapy nomogram, rather than medium risk, as previously done.
Study Design:
A chart review was performed for ABOi newborns born ≥36 weeks gestation between January 2020 and October 2021. Primary outcome measures were rates of phototherapy across pre- and post-intervention groups and among DAT negative newborns.
Results:
There was an increased proportion of newborns assigned to the low risk curve after the intervention. There were no significant differences in phototherapy rates among the intervention groups, although there was a non-significant decrease in phototherapy rates among DAT negative newborns after the intervention. There were no increases in adverse outcomes.
Conclusions:
Providers adhered to the guidelines after implementation of the HCP. ABOi DAT negative newborns can be viewed as low risk for hyperbilirubinemia requiring phototherapy.
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