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Serum Bilirubin Levels and Disease Severity in Patients with Pneumoconiosis
You-Fan Peng1, Jun-Hua Deng1, Xiao-Ying Huang1
1Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China.
Aim:
To investigate the association between serum bilirubin and disease severity in patients with pneumoconiosis.
Methods:
The study comprised 45 patients with pneumoconiosis retrospectively; all pneumoconiosis patients were classified into I, II, and III stage according to the radiological severity.
Results:
Serum direct bilirubin levels were significantly lower in III stage pneumoconiosis patients than those in I/II stage (p = 0.012) but not serum indirect bilirubin. Serum direct bilirubin was negatively correlated with radiological severity in patients with pneumoconiosis (r = -0.320; p = 0.032); by multiple linear-regression analysis, we observed that serum direct bilirubin levels had independent association with radiological severity in patients with pneumoconiosis (beta = -0.459; p = 0.005).
Conclusions:
Serum direct bilirubin levels are negatively associated with disease severity in patients with pneumoconiosis.
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