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Association Between Dietary Cholesterol Intake and Prediabetes: A Population-Based Study
You-Fan Peng1,2, Zihao Shi3, Renjie Yin3
1Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China, gxyyfy.cn.
Background:
Different dietary nutrients are associated with the risk of prediabetes. However, the association between dietary cholesterol intake and prediabetes is unclear. Thus, this study aimed to explore the association between dietary cholesterol intake and prediabetes.
Methods:
Data were extracted and analyzed from the National Health and Nutrition Examination Survey between 2011 and 2016. Self-reported 24-hour dietary recalls were used to evaluate dietary nutrient intake.
Results:
Participants with prediabetes exhibited a significantly higher dietary cholesterol intake compared with those with normoglycemia (241 [156, 367] vs. 263 [168, 381] mg, p = 0.003). Dietary cholesterol intake was significantly positively correlated with fasting blood glucose (r = 0.0607, p < 0.001) and hemoglobin A1c (r = 0.0486, p = 0.007) in all participants. Multivariable logistic regression analysis showed that higher dietary cholesterol intake was independently associated with prediabetes (OR = 1.241, 95% CI: 1.010-1.525, p = 0.040; OR = 1.288, 95% CI: 1.011-1.640, p = 0.040).
Conclusion:
Higher dietary cholesterol intake is independently associated with prediabetes, suggesting that dietary cholesterol intake restriction may be beneficial to prevent prediabetes.
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