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Updated: Aug 5, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Cobalt-Catalyzed Asymmetric Hydrosilylation of α-Oxygenated Ketones
Huiting Wen1, Yifei Chen1, Lanxuan Shi1
1College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China.
Abstract:
An asymmetric hydrosilylation of α-oxygenated ketones was developed under the catalysis of Co(OAc)2 in combination with a chiral phosphine-amido-oxazoline (PAO) ligand, providing a mild, efficient, and enantioselective access to a variety of synthetically useful 1,2-diol derivatives. This protocol can be carried out at the gram scale with a catalyst loading of 1 mol %, and its synthetic utility was demonstrated by efficient conversion of the optically enriched products into chiral α-hydroxy acid, 1,3-dioxolan-2-one, ethylene oxide, and 1,2,3-1H-triazole.
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