Related Experiment Video
Updated: Aug 5, 2025
03:48
Author Spotlight: Exploring the Mysteries of Sichuan's Herbal Medicine in Chinese Medicine Research
Published on: March 1, 2024
1.3K
Targeting the altered duodenal microenvironment in functional dyspepsia
Matthias Ceulemans1, Lucas Wauters2, Tim Vanuytsel2
1Translational Research Center for Gastrointestinal Disorders (TARGID), Department of Chronic Diseases and Metabolism, Katholieke Universiteit Leuven, Leuven, Belgium.
Current Opinion in Pharmacology
|March 24, 2023
Summary
Novel treatments targeting duodenal micro-inflammation and microbial imbalances show promise for functional dyspepsia (FD). Research suggests anti-inflammatory therapies and probiotics can improve symptoms by addressing these underlying duodenal changes.
Area of Science:
- Gastroenterology
- Immunology
- Microbiology
Background:
- Functional dyspepsia (FD) pathophysiology is increasingly linked to duodenal micro-inflammation and microbial dysregulation.
- Current FD treatments have limitations in efficacy and side effect profiles.
Purpose of the Study:
- To explore novel therapeutic strategies for functional dyspepsia (FD) by targeting duodenal alterations.
- To review evidence for anti-inflammatory therapies and probiotics in managing FD symptoms.
Main Methods:
- Review of recent advances in FD research focusing on duodenal inflammation and microbial balance.
- Analysis of studies investigating anti-inflammatory agents and probiotics for FD symptom relief.
Main Results:
- Anti-inflammatory therapies can alleviate gastroduodenal symptoms by reducing duodenal eosinophils and mast cells.
- Probiotics have demonstrated success in restoring microbial homeostasis and improving FD.
Conclusions:
- Targeting duodenal micro-inflammation and dysbiosis offers a promising avenue for novel FD treatments.
- Further research is needed to elucidate the precise mechanisms linking immune activation, dysbiosis, and FD symptoms.
Related Concept Videos
01:24Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
482
Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI) tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining.
482
01:22Pathophysiology of Peptic Ulcer Disease: Injurious Factors
654
Peptic ulcers are sores on the stomach's inner lining and the upper small intestine, which are the result of disruptions in the mucosal layer that houses parietal cells which produce gastric acid, and chief cells which secrete pepsinogen.
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
654
01:30Peptic Ulcer Disease I: Introduction
234
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
234
01:28Peptic Ulcer Disease II: Pathophysiology
617
Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
617
01:28Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
165
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
165
01:26Peptic Ulcer Disease IV: Management
121
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
121