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MicroRNA-based Regulation of Picornavirus Tropism
Published on: February 6, 2017
Possible role of CNS microRNAs in Human Mpox virus encephalitis-a mini-review
Saber Soltani1, Ramin Shahbahrami1, Somaye Jahanabadi2
1Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Abstract:
In May 2022, a re-emerging viral pathogen belonging to the Poxviridae was first reported from the UK, and WHO confirmed the outbreak after the prevalence of the disease increased. As of February 15, 2023, more than 85,000 confirmed cases have been recorded in 110 countries. Due to the spread of the virus across multiple countries, WHO declared the mpox outbreak as a public health emergency. Human mpox virus is an enveloped virus with a linear double-stranded DNA that can cause encephalitis with neurological complications such as pharyngitis, fever, anorexia, adenopathy, vesiculopapular rash, and headache. Dysregulation of microRNAs in viral encephalitis has been reported in a variety of documents. In this mini-review, we aim to discuss the possibility of CNS-related microRNA dysregulation in mpox-related encephalitis.
Insights
Mpox, a viral disease, can cause encephalitis. This review explores how microRNA changes in the central nervous system (CNS) might contribute to mpox-related encephalitis.
Area of Science:
- Virology
- Neuroscience
- Genetics
Background:
- The 2022 mpox outbreak, caused by a Poxviridae virus, became a global public health emergency with over 85,000 cases reported.
- Mpox virus infection can lead to encephalitis, presenting neurological symptoms like fever, rash, and headache.
- MicroRNA dysregulation is a known factor in various viral encephalitis cases.
Purpose of the Study:
- To review the potential role of microRNA dysregulation in the central nervous system (CNS) during mpox-related encephalitis.
- To connect existing knowledge of microRNA in encephalitis with the specific context of mpox.
Main Methods:
- Literature review of scientific documents and reports.
- Analysis of existing research on viral encephalitis and microRNA.
- Synthesis of information regarding mpox virus and its neurological complications.
Main Results:
- Mpox virus, a double-stranded DNA virus, can cause severe neurological complications including encephalitis.
- MicroRNAs are small non-coding RNAs that regulate gene expression and are implicated in neurological disorders.
- Evidence suggests microRNA dysregulation is a common mechanism in viral encephalitis.
Conclusions:
- Central nervous system (CNS)-related microRNA dysregulation is a plausible contributing factor to mpox-related encephalitis.
- Further research is warranted to elucidate the specific microRNA mechanisms involved in mpox encephalitis.
- Understanding these mechanisms could offer new therapeutic targets for mpox neurological complications.
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