Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

5.0K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
5.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of a miRNA-Based Model for Lung Cancer Detection.

Cancers·2025
Same author

Biomarkers in clonal haematopoiesis of indeterminate potential (CHIP) linking cardiovascular diseases, myeloid neoplasms and inflammation.

Annals of hematology·2025
Same author

Utility of ISARIC 4C Mortality Score, Vaccination History, and Anti-S Antibody Titre in Predicting Risk of Severe COVID-19.

Viruses·2024
Same author

Personalized treatment using predictive biomarkers in solid organ malignancies: A review.

Tumori·2024
Same author

Tolerability of Daratumumab Amongst Asian Patients with Plasma Cell Dyscrasias - A Single Centre Experience.

Clinical hematology international·2024
Same author

Graves disease in a patient treated with dupilumab for severe asthma.

Internal medicine journal·2024

Related Experiment Video

Updated: Aug 5, 2025

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples
07:03

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples

Published on: October 2, 2020

4.6K

Advancing biomarker development for diagnostics and therapeutics using solid tumour cancer stem cell models.

Samuel Sherng Young Wang1

  • 1Fast Program, Alexandra Hospital, National University Hospital System, Singapore.

Tumori
|March 25, 2023
PubMed
Summary

The cancer stem cell model explains tumor growth and treatment failure but lacks clinical biomarkers. Better understanding these models is key to developing accurate cancer stem cell biomarkers for diagnostics and therapies.

Keywords:
Cancer stem cellsbiomarkerscancer stem cell modelscancer therapysolid tumourstargeted treatment

More Related Videos

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
07:29

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Published on: June 20, 2015

19.7K
Evaluation of Cancer Stem Cell Migration Using Compartmentalizing Microfluidic Devices and Live Cell Imaging
09:36

Evaluation of Cancer Stem Cell Migration Using Compartmentalizing Microfluidic Devices and Live Cell Imaging

Published on: December 23, 2011

25.4K

Related Experiment Videos

Last Updated: Aug 5, 2025

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples
07:03

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples

Published on: October 2, 2020

4.6K
Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
07:29

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Published on: June 20, 2015

19.7K
Evaluation of Cancer Stem Cell Migration Using Compartmentalizing Microfluidic Devices and Live Cell Imaging
09:36

Evaluation of Cancer Stem Cell Migration Using Compartmentalizing Microfluidic Devices and Live Cell Imaging

Published on: December 23, 2011

25.4K

Area of Science:

  • Oncology
  • Cancer Biology

Background:

  • The cancer stem cell (CSC) model aims to elucidate solid tumor carcinogenesis, progression, and treatment resistance.
  • Despite its potential, the CSC model has yielded limited clinical translation regarding CSC biomarkers and targeted therapies in solid tumors.

Purpose of the Study:

  • This review seeks to stimulate research into clinically translatable CSC biomarkers.
  • It aims to achieve this by defining cancer stem cells and their associated models to improve biomarker accuracy.

Main Methods:

  • Literature review focusing on the cancer stem cell model.
  • Analysis of existing challenges in CSC biomarker development and clinical translation.

Main Results:

  • Current understanding of CSC models is imperfect, hindering biomarker development.
  • Improved comprehension of CSC models is predicted to facilitate the creation of more accurate biomarkers.

Conclusions:

  • Enhanced understanding of CSC models is crucial for developing accurate biomarkers.
  • This understanding will facilitate the clinical translation of biomarkers into diagnostic tools and therapeutic agents for solid tumors.