Personalized treatment using predictive biomarkers in solid organ malignancies: A review

Area of Science:

• Oncology
• Biomarker Research
• Personalized Medicine

Background:

• Biomarkers are increasingly vital in diagnosing and predicting outcomes for solid organ cancers.
• Predictive biomarkers guide personalized treatment strategies, impacting cancer management from initiation to long-term adjustment.

Purpose of the Study:

• To review the application of predictive biomarkers in treating solid organ malignancies.
• To analyze the goals, types, and clinical efficacy of personalized cancer treatment using predictive biomarkers.

Main Methods:

• Literature review focusing on predictive biomarkers in solid organ cancers.
• Analysis of biomarker-guided treatment strategies for common and high-mortality cancers.
• Evaluation of the relative efficacies of predictive biomarkers in clinical settings.

Main Results:

• Predictive biomarkers significantly influence diagnosis, treatment initiation, and monitoring of treatment efficacy and side effects.
• Personalized treatment approaches utilizing predictive biomarkers are effective across diverse solid organ malignancies.
• The review covers colorectal, breast, lung, prostate, pancreatic, liver, kidney, and central nervous system cancers.

Conclusions:

• Predictive biomarkers are essential for advancing personalized oncology and optimizing solid organ malignancy treatment.
• The integration of predictive biomarkers enhances treatment efficacy and patient management in clinical practice.
• Further research into biomarker-driven therapies promises improved outcomes for various cancer types.