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Related Concept Videos

Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
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Non-Canonical Wnt Signaling Pathways01:41

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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
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Stem Cell Niche01:26

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The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Notch Signaling Pathway03:14

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
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Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal01:22

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Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
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Related Experiment Video

Updated: Aug 5, 2025

Modeling Paracrine Noncanonical Wnt Signaling In Vitro
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Wnt signaling in stem cells during development and cell lineage specification.

Rony Chidiac1, Stephane Angers2

  • 1Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.

Current Topics in Developmental Biology
|March 26, 2023
PubMed
Summary

This review details how Wnt/β-catenin signaling guides early embryo development and cell differentiation. This knowledge is used to manipulate signaling for stem cell therapy and regenerative medicine applications.

Keywords:
DevelopmentDifferentiationStem cellsWnt/β-catenin

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Last Updated: Aug 5, 2025

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Area of Science:

  • Developmental biology
  • Cell signaling
  • Regenerative medicine

Background:

  • Embryo development relies on conserved signaling pathways like Wnt, FGF, BMP, and Hedgehog.
  • These pathways regulate cell proliferation, fate, and tissue patterning.
  • Understanding these pathways is crucial for tissue homeostasis and regeneration.

Approach:

  • This review focuses on the Wnt/β-catenin signaling pathway.
  • It examines its role in early embryonic development, axis specification, and cell differentiation.
  • The review highlights the use of small molecules and biologics to modulate Wnt/β-catenin signaling.

Key Points:

  • Wnt/β-catenin signaling is fundamental to early embryonic development.
  • Modulating Wnt/β-catenin signaling enables directed differentiation of pluripotent stem cells.
  • This approach has implications for stem cell therapy and regenerative medicine.

Conclusions:

  • Knowledge of Wnt/β-catenin signaling mechanisms is critical for developmental biology.
  • Targeted manipulation of Wnt/β-catenin signaling offers promising avenues for regenerative medicine.
  • Directed stem cell differentiation holds potential for treating various diseases.