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Automated Robotic Liquid Handling Assembly of Modular DNA Devices
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Modularized synthetic biology enabled intelligent biosensors.

Chao Zhang1, Hao Liu1, Xiujun Li2

  • 1The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P.R. China; Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an 710049, P.R. China.

Trends in Biotechnology
|March 26, 2023
PubMed
Summary

Intelligent synthetic biology-enabled biosensors (SBBs) offer advanced analytical processing for biological detection. This review explores SBBs with computation, memory, and self-calibration for point-of-care testing and wearable monitoring.

Keywords:
intelligent biosensorpoint-of-care testingsynthetic biologywearable monitoring

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Area of Science:

  • Biotechnology
  • Synthetic Biology
  • Biosensor Technology

Background:

  • Biosensors are crucial for biological analysis, detecting target concentrations and producing signals.
  • Intelligent biosensors are gaining interest for their adaptability to complex requirements.
  • Synthetic biology advances enable sophisticated analytical processing in biosensors.

Purpose of the Study:

  • To review intelligent synthetic biology-enabled biosensors (SBBs).
  • To highlight SBBs with computational, memory, and self-calibration capabilities.
  • To discuss emerging applications and future perspectives of SBBs.

Main Methods:

  • Literature review of recent advancements in intelligent SBBs.
  • Focus on SBBs incorporating synthetic biology principles.
  • Analysis of SBBs for computation, memory, and self-calibration.

Main Results:

  • Intelligent SBBs demonstrate capabilities in computation, memory storage, and self-calibration.
  • Emerging applications include point-of-care testing (POCT) and wearable monitoring.
  • Synthetic biology provides a framework for developing advanced SBBs.

Conclusions:

  • Intelligent SBBs represent a significant advancement in biosensor technology.
  • SBBs are poised for impactful applications in healthcare and personal monitoring.
  • Further research in intelligent SBBs promises enhanced analytical capabilities and broader utility.