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Yersinia enterocolitica in Crohn's disease
Xue Fang1, Le Kang1, Yi-Fan Qiu1
1Department of Gastroenterology, Changhai Hospital, Naval Medical University, Shanghai, China.
Frontiers in Cellular and Infection Microbiology
|March 27, 2023
Summary
Yersinia enterocolitica infection may trigger Crohn's disease (CD) pathogenesis. This review explores the link between Y. enterocolitica and CD, discussing diagnostic and therapeutic interventions.
Area of Science:
- Microbiology
- Gastroenterology
- Immunology
Background:
- Gut microbes influence physiological and pathological processes.
- Crohn's disease (CD) is a chronic gastrointestinal inflammatory disease with unknown causes.
- Gastrointestinal infections, including Yersinia enterocolitica, are potential CD triggers.
Purpose of the Study:
- To review the current understanding of Yersinia enterocolitica's role in Crohn's disease pathogenesis.
- To highlight Y. enterocolitica-targeted interventions for CD diagnosis and treatment.
- To suggest future research directions in basic and translational science.
Main Methods:
- Literature review of studies investigating Yersinia enterocolitica and Crohn's disease.
- Analysis of clinical manifestations and etiological factors of CD.
- Examination of microbial compounds and their link to CD pathogenesis.
Main Results:
- Yersinia enterocolitica shares clinical similarities with CD.
- The specific role of Y. enterocolitica in CD remains controversial.
- Y. enterocolitica-targeted interventions show potential in CD diagnosis and treatment.
Conclusions:
- Yersinia enterocolitica and its derived compounds may be implicated in Crohn's disease pathogenesis.
- Further research is needed to elucidate the precise mechanisms and therapeutic potential.
- Investigating the Y. enterocolitica-CD link offers promising avenues for future clinical applications.
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