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Related Experiment Videos

Chronic recurrent multifocal osteomyelitis: a noninfectious inflammatory process.

S M King1, R M Laxer, D Manson

  • 1Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.

The Pediatric Infectious Disease Journal
|October 1, 1987
PubMed
Summary
This summary is machine-generated.

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Chronic recurrent multifocal osteomyelitis (CRMO) is an uncommon childhood bone disease. Research suggests CRMO is a noninfectious inflammatory condition, not a bacterial infection, requiring specific diagnostic and treatment approaches.

Area of Science:

  • Pediatrics
  • Rheumatology
  • Orthopedics

Background:

  • Chronic recurrent multifocal osteomyelitis (CRMO) is a rare pediatric condition of unknown cause.
  • Patients present with insidious bone pain, swelling, and tenderness at multiple sites.

Purpose of the Study:

  • To characterize the clinical presentation and disease course of CRMO.
  • To investigate the etiology and optimal management of CRMO.

Main Methods:

  • Case series of seven pediatric patients diagnosed with CRMO.
  • Clinical evaluation, imaging (scintigraphy, radiography), and bone biopsies were performed.
  • Follow-up ranged from 1 to 3 years.

Main Results:

  • Bone biopsies confirmed osteomyelitis, but no consistent organisms were isolated.

Related Experiment Videos

  • Most patients developed new lesions during follow-up, unresponsive to antibiotics.
  • Two patients had psoriasis; all were seronegative for rheumatoid factor, antinuclear factor, and HLA-B27.

    • Conclusions:

    • CRMO is likely a noninfectious inflammatory condition, potentially a seronegative spondyloarthropathy.
    • Recognition of CRMO is crucial to avoid unnecessary invasive procedures and antimicrobial therapy.
    • CRMO is a chronic condition with potential for long-term exacerbations but is not malignant.