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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Spirocyclization enhances the Diels-Alder reactivities of geminally substituted cyclopentadienes and 4H-pyrazoles

Brian J Levandowski1, Nile S Abularrage1, Ronald T Raines1

  • 1Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States.

Journal of Physical Organic Chemistry
|March 27, 2023
PubMed

Keywords:
Diels–Alder reactionclick chemistrycycloadditiondensity functional theoryspirocycle

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