Related Experiment Video
Updated: Aug 5, 2025

Cecal Ligation and Puncture-induced Sepsis as a Model To Study Autophagy in Mice
Published on: February 9, 2014
Metabolic Reprogramming and Its Regulatory Mechanism in Sepsis-Mediated Inflammation
Wenzhang Liu1, Tianyi Liu1, Yongjun Zheng1
1Department of Burn Surgery, Changhai Hospital, Naval Medical University, Shanghai, 200433, People's Republic of China.
Abstract:
Sepsis is a systemic inflammatory disease caused by an infection that can lead to multiple organ failure. Sepsis alters energy metabolism, leading to metabolic reprogramming of immune cells, which consequently disrupts innate and adaptive immune responses, triggering hyperinflammation and immunosuppression. This review summarizes metabolic reprogramming and its regulatory mechanism in sepsis-induced hyperinflammation and immunosuppression, highlights the significance and intricacies of immune cell metabolic reprogramming, and emphasizes the pivotal role of mitochondria in metabolic regulation and treatment of sepsis. This review provides an up-to-date overview of the relevant literature to inform future research directions in understanding the regulation of sepsis immunometabolism. Metabolic reprogramming has great promise as a new target for sepsis treatment in the future.
Related Concept Videos
Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Regulation of Metabolism
Regulation of the Unfolded Protein Response
Somatic to iPS Cell Reprogramming
Global Regulatory Systems
Other Stress Responses in Bacteria

