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Regulatory T Cells in Diabetic Wound Healing: A Comprehensive Review
Jiezhi Lin1,2, Yingying Liu1, Peiyao Min1
1Department of Burn Surgery, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, People's Republic of China.
Journal of Inflammation Research
|May 29, 2026
Summary
Regulatory T cells (Tregs) are crucial for wound healing in diabetes. This review explores how Tregs impact diabetic wound healing and their therapeutic potential, offering insights into future treatments.
Area of Science:
- Immunology
- Endocrinology
- Regenerative Medicine
Background:
- Diabetic patients often experience impaired wound healing, a significant clinical issue.
- Regulatory T cells (Tregs) play a vital role in modulating immune responses essential for effective wound repair.
- Current understanding of Treg function in diabetic wound healing requires comprehensive synthesis.
Purpose of the Study:
- To review the mechanisms by which Tregs influence wound healing in the context of diabetes.
- To explore the therapeutic potential of Tregs for treating diabetic wounds.
- To identify future research directions and therapeutic strategies for diabetic wound management.
Main Methods:
- A narrative review approach was used to synthesize existing literature.
- Focused on Treg mechanisms affecting inflammation, cellular regeneration, and angiogenesis in diabetic wounds.
- Examined recent advancements in biomaterials, molecular pathways, and Treg-targeting strategies.
Main Results:
- Tregs impact inflammatory responses, cellular regeneration, and angiogenesis in diabetic wound healing.
- Therapeutic strategies involving Tregs show promise, despite challenges like cell acquisition and quality control.
- Clinical advancements suggest Tregs could offer a novel treatment for diabetic complications.
Conclusions:
- Tregs are integral to wound healing and hold significant therapeutic promise for diabetic wounds.
- Further research into Treg-based therapies is warranted to overcome existing challenges.
- Targeting Tregs represents a potential breakthrough in managing chronic diabetic wounds.
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