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Updated: Aug 5, 2025

Optogenetic Random Mutagenesis Using Histone-miniSOG in C. elegans
Published on: November 14, 2016
kin-3 genetically suppresses sur-6 in centrosome assembly during Caenorhabditis elegans embryogenesis
Jeffrey C Medley1, Mi Hye Song1
1Department of Biological Sciences, Oakland University, Rochester, Michigan, United States.
Abstract:
Protein phosphorylation plays a critical role in cell cycle progression. In Caenorhabditis elegans , Casein Kinase II (CK2) negatively regulates centrosome assembly, and Protein Phosphatase 2A (PP2A) SUR-6 /B55 acts as a positive regulator of centrosome duplication, suggesting CK2 and PP2A SUR-6 /B55 play opposing roles in centrosome assembly. Here, we examined the genetic interaction between kin-3 , encoding the catalytic subunit of CK2, and sur-6 , encoding the PP2Aregulatory subunit SUR-6 /B55, in Caenorhabditis elegans embryos. Our results show that kin-3 (RNAi) partially restores normal centrosome duplication and embryonic viability to hypomorphic sur-6 mutants, suggesting that kin-3 genetically suppresses sur-6 in centrosome assembly during Caenorhabditis elegans embryogenesis.
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