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Novel and Innovative Hybrid Technique for Type A Aortic Dissection
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Use of the cardiopulmonary coupling index based on refined composite multiscale entropy for prognostication of acute

Zhi-Jie Mao1, Wei-Wei Wen2, Yi-Chen Han1

  • 1The Key Laboratory of Cardiovascular Disease of Wenzhou, Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Frontiers in Cardiovascular Medicine
|March 27, 2023
PubMed

Insights

Cardiopulmonary coupling (CPC) based on RCMSE effectively predicts complications and death in acute type A aortic dissection (ATAAD) patients. This novel approach aids in risk stratification for better patient outcomes.

Area of Science:

  • Cardiology
  • Thoracic Surgery
  • Biomedical Engineering

Background:

  • The cardiopulmonary system exhibits nonlinear regulation.
  • The relationship between cardiopulmonary coupling (CPC) and postoperative risk in acute type A aortic dissection (ATAAD) remains unstudied.
  • Accurate risk stratification is crucial for managing ATAAD patients.

Purpose of the Study:

  • To assess the predictive value of cardiopulmonary coupling (CPC) using RCMSE for complications and mortality in ATAAD patients.
  • To investigate CPC-RCMSE as a novel biomarker for risk stratification in ATAAD.

Main Methods:

  • A prospective, single-center cohort study enrolled 39 ATAAD patients.
  • Cardiopulmonary coupling (CPC) based on RCMSE was analyzed.
  • Outcomes included in-hospital complications and 2-year all-cause readmission or death.

Main Results:

  • CPC-RCMSE demonstrated strong predictive power for in-hospital complications (AUC=0.853) and 2-year mortality/readmission (AUC=0.731).
  • CPC-RCMSE was identified as an independent predictor of in-hospital complications after adjusting for clinical factors.
  • 41.0% of patients experienced in-hospital complications, and 38.5% faced adverse outcomes within 2 years.

Conclusions:

  • Cardiopulmonary coupling (CPC) based on RCMSE is a valuable independent predictor for in-hospital complications in ATAAD.
  • CPC-RCMSE also predicts 2-year all-cause readmission or death in ATAAD patients.
  • This metric offers a promising tool for enhanced risk stratification in ATAAD management.
Abstract

Keywords:
acute type a aortic dissectioncardiopulmonary couplingcomposite multiscale entropyprognosticationrisk stratification

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