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Correlation analysis between myocardial work indices and liver function classification in patients with hepatitis B
Yang Cao1, Huihui Zhang2, Shuai Li2
1Department of Ultrasound, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, China.
Insights
Left ventricular systolic function is impaired in patients with hepatitis B cirrhosis, with myocardial work indices significantly correlating with liver function severity. This non-invasive technique offers a new method for cardiac evaluation in cirrhosis patients.
Area of Science:
- Cardiology
- Hepatology
- Medical Imaging
Background:
- Liver cirrhosis is strongly linked to cardiac dysfunction.
- Hepatitis B cirrhosis patients exhibit impaired left ventricular systolic function.
- Assessing cardiac function is crucial for managing cirrhosis complications.
Purpose of the Study:
- Evaluate left ventricular systolic function in hepatitis B cirrhosis using the non-invasive left ventricular pressure-strain loop (LVPSL) technique.
- Explore the correlation between myocardial work indices and liver function classification (Child-Pugh).
- Identify independent risk factors for left ventricular myocardial work abnormalities in cirrhosis.
Main Methods:
- 90 hepatitis B cirrhosis patients (Child-Pugh A, B, C) and 30 healthy controls were studied.
- Myocardial work parameters (GWI, GCW, GWW, GWE) were derived from LVPSL.
- Correlation and regression analyses were performed to assess relationships between myocardial work and liver function.
Main Results:
- Global work index (GWI), global constructive work (GCW), and global work efficiency (GWE) were reduced in Child-Pugh B and C groups compared to controls.
- Global wasted work (GWW) was elevated in Child-Pugh B and C groups.
- GWI, GCW, and GWE showed significant negative correlations with liver function severity, while GWW showed a positive correlation.
Conclusions:
- Non-invasive LVPSL effectively identifies changes in left ventricular systolic function in hepatitis B cirrhosis.
- Myocardial work parameters are significantly correlated with liver function classification.
- LVPSL offers a promising new approach for cardiac function assessment in cirrhosis.
Background:
Liver cirrhosis is closely associated with cardiac dysfunction. The aims of this study were to evaluate left ventricular systolic function in patients with hepatitis B cirrhosis by non-invasive left ventricular pressure-strain loop (LVPSL) technique, and to explore the correlation between myocardial work indices and liver function classification.
Methods:
According to the Child-Pugh classification, 90 patients with hepatitis B cirrhosis were further divided into three groups: Child-Pugh A group (n = 32), Child-Pugh B group (n = 31), and Child-Pugh C group (n = 27). During the same period, 30 healthy volunteers were recruited as the control (CON) group. Myocardial work parameters, which included global work index (GWI), global constructive work (GCW), global wasted work (GWW), and global work efficiency (GWE), were derived from the LVPSL and compared among the four groups. The correlation between myocardial work parameters and Child-Pugh liver function classification was evaluated, and the independent risk factors affecting left ventricular myocardial work in patients with cirrhosis were investigated by univariable and multivariable linear regression analysis.
Results:
GWI, GCW and GWE of Child-Pugh B and C groups were lower than those of CON group, while GWW was higher than that of CON group, and the changes were more obvious in Child-Pugh C group (P < 0.05). Correlation analysis revealed that GWI, GCW, and GWE were negatively correlated with liver function classification to various degrees (r = -0.54, -0.57, and -0.83, respectively, all P < 0.001), while GWW was positively correlated with liver function classification (r = 0.76, P < 0.001). Multivariable linear regression analysis showed that GWE was positively correlated with ALB (β = 0.17, P < 0.001), and negatively correlated with GLS (β = -0.24, P < 0.001).
Conclusions:
The changes in the left ventricular systolic function in patients with hepatitis B cirrhosis were identified using non-invasive LVPSL technology, and myocardial work parameters are significantly correlated with liver function classification. This technique may provide a new method for the evaluation of cardiac function in patients with cirrhosis.
